Kenneth Kosik, M.D.
Harriman Professor of Neuroscience Research, MCDB, Co-Director, Neuroscience Research Institute, BMSE
microRNAs: A Novel Class of Targets for Medical Intervention
microRNAs are small non-coding transcripts that regulate the translation or stability of multiple mRNAs. Important roles for microRNAs have been suggested in development, neural plasticity and cancer. Their simple structures and ability to design inhibitors based on Watson-Crick base pairing principles opens a novel target space. Because microRNAs can regulate a large number of mRNAs that may share common functions, targeting critical microRNAs in a disease pathway may serve as a validation or intervention strategy.
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