Joel Rothman, Ph.D.
Professor, MCDB, BMSE
Aging and age-related disease
Programmed cell death (apoptosis), a key process underlying human age-related disorders, including neurodegeneration and cancer, provides a promising target for therapeutic intervention in many pathologies. Moreover, replacement of senescent or damaged cells is crucial for youthfulness and treatment of degenerative cell loss. We are using large-scale functional genomics methods to characterize the regulatory networks for cell death and renewal. The pathways emerging from these networks promise to identify new targets for drug design and suggest genetic modifications that might be used to generate new classes of multipotential stem cells from differentiated tissue.
Watch the Presentation - 24 min.
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